NeuroGenetics
← All Modules
Search
⌘K
Dashboard
Review
Pharmacogenetics in Neurology
1 / 5
Question 1
A woman with epilepsy on a stable lamotrigine dose delivers her baby. Two weeks postpartum, she develops diplopia, ataxia, and nausea. Her lamotrigine level is found to be twice the pre-pregnancy target. The most likely explanation is:
A
Postpartum depression is causing psychosomatic symptoms that mimic lamotrigine toxicity but are unrelated to drug levels
B
Breastfeeding increases lamotrigine absorption from the gut, leading to supratherapeutic maternal serum concentrations
C
Postpartum estrogen decline reverses UGT1A4 induction, reducing lamotrigine clearance — the pregnancy dose causes toxicity
D
Postpartum autoimmune hepatitis has impaired all hepatic drug metabolism including lamotrigine glucuronidation
Next Question